Bleeding Disorders

Bleeding Disorders

Bleeding disorders are usually taken to mean coagulopathies with reduced clotting of the blood but also encompass disorders characterised by abnormal platelet function or blood vessel walls that result in increased bleeding. Bleeding disorders may result from faults at many different levels in the coagulation process. They can range from severe and life-threatening conditions, such as haemophil...

Bleeding Disorders: Hemorrhagic Diatheses

Before discussing these specific bleeding disorders, it is helpful to review normal hemostasis ( Chapter 4 ) and the common laboratory tests used in the evaluation of a bleeding diathesis. It should be recalled from the discussion in Chapter 4 that the normal hemostatic response involves the blood vessel wall, the platelets, and the clotting cascade. Tests used to evaluate different aspects of ...

Acquired bleeding disorders.

tial acquired bleeding disorder is common in clinical practice. The most common cause is anticoagulant therapy, including antiplatelet drugs. With increasing use of pharmacological thromboprophylaxis in both medical and surgical inpatients and increasing indications for long-term antithrombotic therapy, it is imperative to consider drug-induced bleeding during the initial evaluation of abnormal...

Bleeding Disorders in Animals

Rare bleeding disorders.

During the haemostatic response, the formation of a primary platelet plug limits bleeding and provides a surface for clotting factors to assemble and become activated. The initial platelet plug is stabilized by fibrin monomers, covalently cross-linked by FXIII, forming a platelets-fibrin thrombus. Defects in platelets as well as inherited deficiencies of coagulation factors including fibrinogen...